| Position | Player | Club | Age | Caps |
|---|---|---|---|---|
| Goalkeeper | Fernando Muslera | Galatasaray (TUR) | 36 | 133 |
| Goalkeeper | Sergio Rochet | Nacional (URU) | 29 | 8 |
| Goalkeeper | Sebastian Sosa | Independiente (ARG) | 36 | 1 |
| Defender | Ronald Araujo | Barcelona (ESP) | 23 | 12 |
| Defender | Martin Caceres | LA Galaxy (USA) | 35 | 115 |
| Defender | Sebastian Coates | Sporting CP (POR) | 32 | 47 |
| Defender | Jose Maria Gimenez | Atletico Madrid (ESP) | 27 | 78 |
| Defender | Diego Godin | Velez Sarsfield (ARG) | 36 | 159 |
| Defender | Mathias Olivera | Napoli (ITA) | 24 | 8 |
| Defender | Jose Luis Rodriguez | Nacional (URU) | 25 | 9 |
| Defender | Guillermo Varela | Flamengo (BRA) | 29 | 9 |
| Defender | Matias Vina | AS Roma (ITA) | 24 | 26 |
| Midfielder | Rodrigo Bentancur | Tottenham (ENG) | 25 | 51 |
| Midfielder | Nicolas De La Cruz | River Plate (ARG) | 25 | 17 |
| Midfielder | Facundo Pellistri | Manchester United (ENG) | 20 | 7 |
| Midfielder | Lucas Torreira | Galatasaray (TUR) | 26 | 40 |
| Midfielder | Manuel Ugarte | Sporting CP (POR) | 21 | 6 |
| Midfielder | Federico Valverde | Real Madrid (ESP) | 24 | 44 |
| Midfielder | Matias Vecino | Lazio (ITA) | 31 | 62 |
| Forward | Agustin Canobbio | Athletico Paranaense (BRA) | 24 | 3 |
| Forward | Edinson Cavani | Valencia (ESP) | 35 | 133 |
| Forward | Giorgian De Arrascaeta | Flamengo (BRA) | 28 | 40 |
| Forward | Maxi Gomez | Trabzonspor (TUR) | 26 | 27 |
| Forward | Darwin Nunez | Liverpool (ENG) | 23 | 13 |
| Forward | Luis Suarez | Nacional (URU) | 35 | 134 |
| Forward | Facundo Torres | Orlando City (USA) | 22 | 10 |
Source: sportingnews
